PGT-M
What is it?
For people who know they are at increased risk of passing on a specific genetic condition, PGT-M, or preimplantation genetic testing for monogenic/single gene defects, can be performed prior to pregnancy to greatly reduce the risk of having an affected child. PGT-M for single gene disorders involves testing embryos created through in vitro fertilization (IVF) and then transferring unaffected embryos. PGT-M was formerly known as PGD, preimplantation genetic diagnosis.
Who it's for?
- You and your partner are carriers of the same autosomal recessive condition (e.g. Cystic fibrosis)
- You are a carrier of an X-linked condition (e.g. Duchenne Muscular Dystrophy)
- You or your partner have an autosomal dominant condition (e.g. Huntington disease)
- You or your partner have a mutation associated with a hereditary cancer syndrome (e.g. BRCA1 & 2)
- You had a child or pregnancy with a single gene disorder
- You want to perform HLA matching
How it works?
PGT-M tests are created uniquely for each family. PGT-M can be performed for nearly any single gene disorder as long as the specific familial mutation has been identified and appropriate family members are available for test preparation.
PGT-A
What is it?
PGT-A, or preimplantation genetic testing for aneuploidies, is a genetic test performed on embryos produced through IVF. PGT-A gives information about embryos’ genetic health to help your care team select the best embryo for transfer and improve your chance of achieving a successful pregnancy. PGT-A was formerly known as PGS, preimplantation genetic screening.
Who it's for?
PGT-A is appropriate for the vast majority of people undergoing IVF.
All women are at risk of producing chromosomally abnormal embryos. As a woman ages, the potential for chromosomally abnormal embryos significantly increases, regardless of the number of embryos produced.
PGT-A can help women of all ages increase their chances of a successful pregnancy.
How it works?
PGT-A works by looking at the amount of genetic material within IVF embryos. This genetic material is housed within structures called chromosomes. Chromosomes are very important for healthy growth and development.
Embryos with the incorrect number of chromosomes (also called aneuploid embryos) typically do not result in a successful pregnancy or may lead to the birth of a child with a genetic condition.
Embryos with the correct number of chromosomes (also called euploid embryos) have a better chance of leading to a successful pregnancy.
PGT-A identifies embryos with the correct number of chromosomes, so your care team can select the embryo with the best chance of leading to IVF success.
Location
Dr Surinder Singh Fertility Specialist
2nd Floor, Room F1, Thomson Hospital Kota Damansara